EPZ-719

EPZ-719 is a selective, orally effective SETD2 inhibitor with an IC50 value of 0.005 μM. EPZ-719 has anticancer activity[1].

Product Specifications

CAS Number

[2697176-16-0]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/epz-719.html

Purity

99.00

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=C2C(C=C(C(N[C@@H]3CCC[C@H](N4C[C@@H](N(S(=O)(C)=O)C)CC4)C3)=O)N2)=C(F)C=C1

Molecular Formula

C22H31FN4O3S

Molecular Weight

450.57

References & Citations

[1]Lampe JW, et al. Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies. ACS Med Chem Lett. 2021 Aug 24;12 (10) :1539-1545.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SETD2/KMT3A

Available Sizes

Curated Selection

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