Recombinant Human CCL27
Recombinant human CCL27
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
rHuCCL27, CTACK
Gene Name
CCL27
UniProt
Q9Y4X3
Cellular Locus
Secreted
Reactivity
Human
Target Antigen
C-C motif chemokine 27
Target
CCL27
Type
Protein
Applications
Migration assay
Dilution
Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
Form
Lyophilized
Function
Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.
Additionnal Information
Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in L1.2 cells expressing CCR10.
Storage Conditions
12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution.
Product Datasheet
https://www.qedbio.com/wp-content/uploads/pdf/50182P.pdf
Specificity
CCL27
Target Background
CCL27, also known as Cutaneous T-cell-attracting Chemokine (CTACK) is a ligand for cell surface receptor CCR10. It is responsible for chemotaxis of skin-homing memory T-cells during cutaneous inflammation. Interestingly, after CCR10-mediated internalization, CCL27, as well as a non-secreted splice variant of the same gene, can reach the nucleus and modulate transcription and cell behavior.
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