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TEAD-IN-10

TEAD-IN-10 (compound 15) has good selective activity and inhibitory effect on TEAD1 (IC50=14 nM), TEAD2 (IC50=179 nM) and TEAD3 (IC50=4 nnM) as a covalent inhibitor. TEAD-IN-10 can be used for cancer research[1].

Product Specifications

CAS Number

3032196-65-6

UNSPSC

12352005

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tead-in-10.html

Solubility

10 mM in DMSO

Smiles

O=C(C=C)N(C1)CC1/C=C/C2=CC=C(C(F)(F)F)C=C2

Molecular Formula

C15H14F3NO

Molecular Weight

281.27

References & Citations

[1]Henry William, et al. Yap/taz-tead oncoproteins inhibitors.WO2024059317A1.2023-09-15

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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