SHMT-IN-1
Product Specifications
UNSPSC Description
SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). SHMT-IN-1 has antitumor activity[1].
Target Antigen
SHMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shmt-in-1.html
Purity
99.79
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
N#CC(C1(C2CCC2)C3=CC(Cl)=CC(Cl)=C3)=C(N)OC4=C1C(C)=NN4
Molecular Weight
375.25
References & Citations
[1]Witschel MC, et al. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. J Med Chem. 2015 Apr 9;58(7):3117-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129651/SHMT-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129651/SHMT-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1508286-18-7
Available Sizes
Curated Selection
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