SHMT-IN-1

SHMT-IN-1 (compound (±) -46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT) . SHMT-IN-1 has antitumor activity[1].

Product Specifications

CAS Number

[1508286-18-7]

UNSPSC

12352005

Target

SHMT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shmt-in-1.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

N#CC(C1(C2CCC2)C3=CC(Cl)=CC(Cl)=C3)=C(N)OC4=C1C(C)=NN4

Molecular Formula

C18H16Cl2N4O

Molecular Weight

375.25

References & Citations

[1]Witschel MC, et al. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) : cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. J Med Chem. 2015 Apr 9;58 (7) :3117-30.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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