SHMT-IN-1
SHMT-IN-1 (compound (±) -46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT) . SHMT-IN-1 has antitumor activity[1].
Product Specifications
CAS Number
[1508286-18-7]
UNSPSC
12352005
Target
SHMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shmt-in-1.html
Concentration
10mM
Purity
99.86
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
N#CC(C1(C2CCC2)C3=CC(Cl)=CC(Cl)=C3)=C(N)OC4=C1C(C)=NN4
Molecular Formula
C18H16Cl2N4O
Molecular Weight
375.25
References & Citations
[1]Witschel MC, et al. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) : cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. J Med Chem. 2015 Apr 9;58 (7) :3117-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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