MMP-7-IN-3

MMP-7-IN-3 is a potent and selective inhibitor of MMP-7. MMP-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction[1].

Product Specifications

CAS Number

[2865097-58-9]

UNSPSC

12352209

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mmp-7-in-3.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(N[C@H](C(O)=O)CCC(NCC(N[C@@H](CC1=CC=NC=C1)C(N[C@@H](C(C)(C)C)C(N2[C@@H](CCC2)CC(N)=O)=O)=O)=O)=O)(C3=CC(C(F)(F)F)=C(C=C3)Cl)=O

Molecular Formula

C34H43ClF3N7O9S

Molecular Weight

818.26

References & Citations

[1]Abe-Sato K, et al. Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis. J Med Chem. 2023 Oct 20.