PROTAC Bcl2 degrader-1
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN) -binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1] (Blue: CRBN ligand, Black: linker; Pink: Mcl-1/Bcl-2 inhibitor, Nap-1) .
Product Specifications
CAS Number
2378801-85-3
UNSPSC
12352005
Target
Bcl-2 Family; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl2-in-1.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O
Molecular Formula
C45H45BrN6O10S
Molecular Weight
941.84
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Mcl-1
Available Sizes
Frequently Asked Questions
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