NLRP3/AIM2-IN-3
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization[1].
Product Specifications
CAS Number
[1787787-60-3]
UNSPSC
12352005
Target
AIM2; NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-aim2-in-3.html
Purity
98.23
Solubility
DMSO : 250 mg/mL (ultrasonic) |Methanol : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3
Molecular Formula
C16H14N2O2
Molecular Weight
266.29
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Available Sizes
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