NLRP3/AIM2-IN-3
Product Specifications
UNSPSC Description
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization[1].
Target Antigen
AIM2; NOD-like Receptor (NLR); Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-aim2-in-3.html
Solubility
DMSO : 250 mg/mL (ultrasonic)|Methanol : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3
Molecular Weight
266.29
References & Citations
[1]Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144226/NLRP3-AIM2-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144226/NLRP3-AIM2-IN-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1787787-60-3
Available Sizes
Curated Selection
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