NLRP3/AIM2-IN-3

NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization[1].

Product Specifications

CAS Number

[1787787-60-3]

UNSPSC

12352005

Target

AIM2; NOD-like Receptor (NLR) ; Pyroptosis

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nlrp3-aim2-in-3.html

Purity

98.23

Solubility

DMSO : 250 mg/mL (ultrasonic) |Methanol : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3

Molecular Formula

C16H14N2O2

Molecular Weight

266.29

References & Citations

[1]Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.