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ASCT2-IN-1

ASCT2-IN-1 (compound 20k) is an ASCT2 inhibitor with IC50 values of 5.6 μM and 3.5 μM in cells A549 and HEK293, respectively. ASCT2-IN-1 induces cell apoptosis. ASCT2-IN-1 inhibits tumor growth[1].

Product Specifications

CAS Number

3032651-18-3

UNSPSC

12352005

Target

Apoptosis; ASCT; Autophagy; mTOR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/asct2-in-1.html

Concentration

10mM

Purity

98.21

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@@H](CCN(CC1=C(C=CC=C1)OCC#CC2=CC=C(C=C2)Cl)CC3=CC=CC=C3OCC#CC4=CC=C(C=C4)Cl)C(O)=O

Molecular Formula

C36H32Cl2N2O4

Molecular Weight

627.56

References & Citations

[1]Qin L, et al., Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2024 Jan 13. doi: 10.1021/acs.jmedchem.3c01093

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ASCT2

Available Sizes

Frequently Asked Questions

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