ASCT2-IN-1

ASCT2-IN-1 (compound 20k) is an ASCT2 inhibitor with IC50 values of 5.6 μM and 3.5 μM in cells A549 and HEK293, respectively. ASCT2-IN-1 induces cell apoptosis. ASCT2-IN-1 inhibits tumor growth[1].

Product Specifications

CAS Number

[3032651-18-3]

UNSPSC

12352005

Target

Apoptosis; ASCT; Autophagy; mTOR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/asct2-in-1.html

Concentration

10mM

Purity

98.21

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N[C@@H](CCN(CC1=C(C=CC=C1)OCC#CC2=CC=C(C=C2)Cl)CC3=CC=CC=C3OCC#CC4=CC=C(C=C4)Cl)C(O)=O

Molecular Formula

C36H32Cl2N2O4

Molecular Weight

627.56

References & Citations

[1]Qin L, et al., Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2024 Jan 13. doi: 10.1021/acs.jmedchem.3c01093

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ASCT2

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MCH03023 2x 2.5 nmol

hsa-miR-548f-5p miRNA Mimic

Ask

View Details

GR111160 96 Well

Nori® Human IL-22 ELISA Kit

Ask

View Details

RC220918L4 10 µg

Alkyl DHAP synthase (AGPS) (NM_003659) Human Tagged Lenti ORF Clone

Ask

View Details

MR203469L4 10 µg

AU019823 (NM_212449) Mouse Tagged Lenti ORF Clone

Ask

View Details