25 (R, S) -Ruscogenin

Ruscogenin suppresses HCC metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF and HIF-1α via regulating the PI3K/Akt/mTOR signaling pathway[1]. And Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by su

Product Specifications

CAS Number

[874485-32-2]

UNSPSC

12352005

Target

Akt; Apoptosis; mTOR; PI3K

Type

Natural Products

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/25-r-s-ruscogenin.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](C[C@H]5O)O)=CC4)C)([H])CC2)([H])O[C@]6(CCC(CO6)C)[C@H]3C

Molecular Formula

C27H42O4

Molecular Weight

430.62

References & Citations

[1]Hua H, Zhu Y, Song YH. Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway. Biomed Pharmacother. 2018;101:115-122.|[2]Wu Y, Wang Y, Gong S, et al. Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by suppressing TLR4 signaling. Biomed Pharmacother. 2020;125:109868.