NPR-C activator 1
NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C) . C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ∼ 1 μM) with promising in vivo pharmacokinetic properties[1].
Product Specifications
CAS Number
2768328-61-4
UNSPSC
12352005
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/npr-c-activator-1.html
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(NC1=CC=C(C=C1)NC2=NC=NC(NCCC(OC(C)(C)C)=O)=N2)=O
Molecular Formula
C18H24N6O3
Molecular Weight
372.42
References & Citations
[1]Smith RJ, et al. A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem. 2022 Apr 14;65 (7) :5495-5513.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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