Eflornithine (hydrochloride)

Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

Product Specifications

CAS Number

[68278-23-9]

Product Name Alternative

DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/eflornithine-hydrochloride.html

Purity

99.90

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

NC(CCCN)(C(F)F)C(O)=O.[H]Cl

Molecular Formula

C6H13ClF2N2O2

Molecular Weight

218.63

Precautions

H302, H312, H332

References & Citations

[1]Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.|[2]Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2 (3) :197-201; discussion 202.|[3]Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23 (5) :1495-501.|[4]Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19 (3) :297-312.