PROTAC eEF2K degrader-1

PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation[1].

Product Specifications

CAS Number

[2458170-54-0]

UNSPSC

12352005

Target

Apoptosis; CaMK; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-eef2k-degrader-1.html

Purity

98.64

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCN1C(N(C(C2=C1N=C(C(C(N)=O)=C2)N)=O)CC(NCCOCCNC(COC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)=O)=O

Molecular Formula

C31H33N9O11

Molecular Weight

707.65

References & Citations

[1]Yao Liu, et al. Designing an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. Eur J Med Chem. 2020 Oct 15;204:112505.