Idoxuridine

Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1]. Idoxuridine shows anti-orthopoxvirus activity.

Product Specifications

CAS Number

[54-42-2]

Product Name Alternative

5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H341, H361

Target

Orthopoxvirus; Phosphatase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Idoxuridine.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(I)C1=O

Molecular Formula

C9H11IN2O5

Molecular Weight

354.10

Precautions

H315, H319, H335, H341, H361

References & Citations

[1]David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65 (4) :399-403.|[2]D E Griswold, et al. Stimulation of hemolysin plaque-forming cells by idoxuridine. Cancer Res. 1975 Jan;35 (1) :88-92.|[3]Mark N Prichard, et al. Orthopoxvirus targets for the development of antiviral therapies. Curr Drug Targets Infect Disord