4-PQBH

4-PQBH is a potent Nur77 binder (KD=1.17 μM) . 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research[1].

Product Specifications

CAS Number

[2243355-51-1]

Product Name Alternative

CNS 1102 (free base)

UNSPSC

12352005

Target

Nuclear Hormone Receptor 4A/NR4A; Paraptosis

Type

Reference compound

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-pqbh.html

Concentration

10mM

Purity

99.14

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N/N=C/C1=CC=NC=C1)C2=CC=C(NC3=CC=NC4=CC=CC=C34)C=C2

Molecular Formula

C22H17N5O

Molecular Weight

367.40

References & Citations

[1]Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651.