ZYZ-488
Product Specifications
UNSPSC Description
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3[1].
Target Antigen
Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zyz-488.html
Purity
99.80
Solubility
DMSO : 200 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
Smiles
O=C(OCCCCNC(N)=N)C(C=C1OC)=CC(OC)=C1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O2
Molecular Weight
487.46
References & Citations
[1]Wang Y, et al. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification. Sci Rep. 2016 Jul 22;6:29820.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100472/ZYZ-488-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100472/ZYZ-488-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1470302-79-4
Available Sizes
Curated Selection
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