BR103
BR103 is a C3aR-specific small molecule ligand. BR103 can be used to measure ligand affinity for a G protein-coupled receptor for saturation and competitive binding[1].
Product Specifications
CAS Number
1434873-26-3
UNSPSC
12352005
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/br103.html
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N=C(N)NCCC[C@@H](C(O)=O)NC(C1=C(C)N=C(C(C2=CC=CC=C2)C3=CC=CC=C3)N1)=O
Molecular Formula
C24H28N6O3
Molecular Weight
448.52
References & Citations
[1]Dantas de Araujo A, et al. Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor. Bioconjug Chem. 2017 Jun 21;28 (6) :1669-1676.|[2]Lohman RJ, et al. Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nat Commun. 2017 Aug 24;8 (1) :351.|[3]Rowley JA, et al. Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity. J Med Chem. 2020 Jan 23;63 (2) :529-541.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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