Tominersen (sodium)

Tominersen sodium is a second-generation 2′-O- (2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen sodium can be used for the research of Huntington’s disease (HD) [1][2].

Product Specifications

Product Name Alternative

RG6042 (sodium) ; IONIS-HTTRx (sodium)

UNSPSC

12352208

Target

Huntingtin

Type

Oligonucleotides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tominersen-sodium.html

Purity

97.36

Solubility

10 mM in H2O

Smiles

[Tominersen(sodium)]

Molecular Formula

C230H299N74Na20O122P19S13

Molecular Weight

7078 (free acid)

References & Citations

[1]Kordasiewicz HB, et al. Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron. 2012 Jun 21;74 (6) :1031-44.|[2]Tabrizi SJ, et, al. Targeting Huntingtin Expression in Patients with Huntington's Disease. N Engl J Med. 2019 Jun 13;380 (24) :2307-2316.