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Nav1.1 activator 1

Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6[1].

Product Specifications

CAS Number

2332897-85-3

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nav1-1-activator-1.html

Concentration

10mM

Purity

98.98

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C2=CC(F)=CC=C2F)C=CN=C1N3C[C@@H](F)CC3)NC4=CC=C(C(C)C)N=C4

Molecular Formula

C24H23F3N4O

Molecular Weight

440.46

References & Citations

[1]Miyazaki T, et al. Discovery of novel 4-phenyl-2- (pyrrolidinyl) nicotinamide derivatives as potent Nav1.1 activators. Bioorg Med Chem Lett. 2019 Mar 15;29 (6) :815-820.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Nav1.1

Available Sizes

Frequently Asked Questions

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