Nav1.1 activator 1
Nav1.1 activator 1 (compound 4), a highly potent Nav1.1 activator with BBB penetration, increases decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6[1].
Product Specifications
CAS Number
[2332897-85-3]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-1-activator-1.html
Concentration
10mM
Purity
98.98
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=CC(F)=CC=C2F)C=CN=C1N3C[C@@H](F)CC3)NC4=CC=C(C(C)C)N=C4
Molecular Formula
C24H23F3N4O
Molecular Weight
440.46
References & Citations
[1]Miyazaki T, et al. Discovery of novel 4-phenyl-2- (pyrrolidinyl) nicotinamide derivatives as potent Nav1.1 activators. Bioorg Med Chem Lett. 2019 Mar 15;29 (6) :815-820.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.1
Available Sizes
Curated Selection
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