Hupehenine

Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders[1][2][3][4].

Product Specifications

CAS Number

[98243-57-3]

UNSPSC

12352005

Target

Apoptosis; Autophagy; Parasite; Reactive Oxygen Species (ROS) ; α-synuclein

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hupehenine.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1CC[C@@]2(C)[C@]([C@H](O)C[C@]3([H])[C@]2([H])C[C@]4([H])[C@@]3([H])CC[C@]5([H])[C@@]4([H])CN6[C@](CC[C@H](C)C6)([H])[C@@H]5C)([H])C1

Molecular Formula

C27H45NO2

Molecular Weight

415.65

References & Citations

[1]Wu X, et al. Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species. J Ethnopharmacol. 2018 Jan 10;210:39-46.|[2]Xin M, et al. Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors. Bioorg Med Chem. 2014 Feb 15;22 (4) :1429-40.|[3]Ghanem SS, et al. Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity. Molecules. 2021 Jun 19;26 (12) :3736.|[4]Wen C, et al. Determination and validation of hupehenine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study. Biomed Chromatogr. 2015 Dec;29 (12) :1805-10.|[5]Menpadi N, et al. Molecular Mechanisms of Cell Death in Leishmania donovani Induced by Selected Steroidal Alkaloids. J Basic Microbiol. 2025 Mar;65 (3) :e2400655.