SynaptoGreenTM C3 Nerve Terminal Dye

Nerve terminal dyes have highly hydrophilic, cationically charged head groups at one end with lipophilic tails at the other end. They are virtually non-fluorescent in aqueous solution, but become intensely fluorescent in membranes. Following nerve stimulation, the dye molecules are internalized in newly formed endocytic vesicles. During exocytosis, the dyes are released from the vesicles along with neurotransmitters, causing a decrease in fluorescence signal. As a result, the change in fluorescent intensity reflects the amount of endocytosis/exocytosis or synaptic activity. SynaptoGreenTM C3 is a widely used green fluorescent dye for following synaptic activity by staining synaptic vesicles at the synapse or neuromuscular junctions. When used in combination with the red fluorescent dye SynaptoRedTM , synapses or neuromuscular junctions can be imaged independently in two colors. SynaptoGreenTM C3 is similar to SynaptoGreenTM C4 (70020), except that the lipophilic tail is one carbon shorter and also the hydrophilic end is a trimethylammonium group.

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.