Alpha-Bungarotoxin, Tetramethylrhodamine Conjugate

Alpha-Bungarotoxin is a high affinity inhibitor (Kd = 1 nM to 1 pM) of the nicotinic acetylcholine receptor in the neuromuscular junction and blocks acetylcholine activity at the postsynaptic membrane. It is often used to study neuromuscular junctions by blocking cholinergic receptors. The effects of α-bungarotoxin on neuronal nAChR have been shown to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 μM) . Labeled α-bungarotoxin conjugates can be used for staining nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections.

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