Alpha-Bungarotoxin, Fluorescein Conjugate
Our alpha-Bungarotoxin is a potent neurotoxin widely used to study neuromuscular junctions by blocking cholinergic receptors. Our fluorescein conjugate is membrane impermeant and works well in live/intact cells and cells fixed in formaldehyde or methanol.
Product Specifications
Background
Alpha-Bungarotoxin is a high affinity inhibitor (Kd = 1 nM to 1 pM) of the nicotinic acetylcholine receptor in the neuromuscular junction and blocks acetylcholine activity at the postsynaptic membrane. It is often used to study neuromuscular junctions by blocking cholinergic receptors. The effects of α-bungarotoxin on neuronal nAChR have been shown to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 μM) . Labeled α-bungarotoxin conjugates can be used for staining nicotinic acetylcholine receptors at neuromuscular junctions in tissue sections.
Synonyms
Neurotoxin, nicotinic (a7) receptor antagonist
Type
Dyes & Tracing Reagents
Applications
ICC, IHC, EM
Shipping Conditions
Shipped at ambient temperature with desiccant; protected from light
Storage Conditions
Store at –20°C, with desiccant; protect from light.
Specificity
Membrane impermeant; works in live/intact cells and cells fixed in formaldehyde or methanol.
Recommended Usage
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
Physical Properties
Solid
Conjugate
FITC Ex: 498 nm, Em: 517 nm
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