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Anti-GABA-A-R-Gamma2L/S Antibody

Our Anti-GABA-A-R-Gamma2L/S mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N452/73. It detects human, mouse, and rat GABA-A-R-Gamma2L/S, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Gamma-aminobutyric acid receptor subunit gamma-2, or GABA AR gamma2 is encoded by the gene GABRG2. GABA A receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR gamma2 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR gamma2 has been found expressed in stomach and bladder. In brain, GABA AR gamma2 is expressed at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Mutations in this gene have been associated with epilepsy and febrile seizures. Note that GABA AR γ2 subunit has two forms, designated “short” (γ2S) and “long” (γ2L) that differ only in eight amino acids inserted into the large intracellular loop of the subunit (Whiting et al., 1990) .

Short Description

Our Anti-GABA-A-R-Gamma2L/S mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N452/73. It detects human, mouse, and rat GABA-A-R-Gamma2L/S, and is purified by protein a chromatography. It is great for use in IHC, ICC, ELISA.

Synonyms

GABA-A-R-Gamma2L Gamma-aminobutyric acid receptor subunit gamma-2) (GABRG2)

Gene Name

Ano3 Tmem16c

UniProt

P18507-2

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 360-445 (cytoplasmic C-terminus) of human GABA-A-R-Gamma2L (accession number P18507-2) produced recombinantly in E. Coli

Target

GABA-A-R-Gamma2L/S

Clonality

Monoclonal

Isotype

IgG1

Clone

N452/73

Type

Primary Antibody

Applications

IHC, ICC, ELISA

Field of Research

Neurotransmitter Receptors

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

45-55 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

Conjugate

Unconjugated

IHC Quality Control

1

RRID

AB_2725815

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