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Anti-Kv6.4 Potassium Channel Antibody

Our Anti-Kv6.4 potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N458/10. It detects mouse and rat Kv6.4 potassium channel, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Product Specifications

Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999) . Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. Members of the Kv5-Kv11 families code for “silent subunits” that do not express as functional homomultimers. In heterologous expression systems, silent subunits can coassemble with Kv2 and Kv3 subunits and modulate the biophysical characteristics of the latter subunits (Yan L. et al., 2004) .

Short Description

Our Anti-Kv6.4 potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N458/10. It detects mouse and rat Kv6.4 potassium channel, and is purified by protein a chromatography. It is great for use in WB, ICC, ELISA.

Synonyms

Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4)

Gene Name

Kcng4

UniProt

Q80XM3

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Fusion protein amino acids 1-219 (cytoplasmic N-terminus) of mouse Kv6.4 (accession number Q80XM3) produced recombinantly in E. Coli

Target

Kv6.4 potassium channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

N458/10

Type

Primary Antibody

Applications

WB, ICC, ELISA

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

60-80 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

ICC Quality Control

1

Conjugate

Unconjugated

RRID

AB_2716262

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