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Anti-Navbeta1 Na+ Channel Antibody (BSA and Azide free)

Our carrier-free Anti-Navbeta1 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N405/74. It detects mouse and rat Navbeta1 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Sodium channel subunit beta-1or Navbeta1 Na+ channel is encoded by SCN1B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. SCN1B has two splice variants. Navß1 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel inactivation. It is found expressed in brain, spinal cord, heart and skeletal muscle. Diseases associated with SCN1B include several types of epilepsy.

Short Description

Our Anti-Navbeta1 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N405/74. It detects mouse and rat Navbeta1 Na+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC, ELISA.

Synonyms

Sodium channel subunit beta-1

Gene Name

Scn1b

UniProt

Q00954

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Fusion protein amino acids 14-160 (extracellular N-terminus) of rat Navbeta1 (accession number Q00954) produced recombinantly in E. Coli

Target

Navbeta1 Na+ channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

N405/74

Type

Primary Antibody

Applications

IHC, ICC, ELISA

Field of Research

Ion Channels and Modulators/Na+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS

Molecular Weight

24 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Navbeta2, Navbeta3 or Navbeta4

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

Unconjugated

Frequently Asked Questions

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