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Anti-Nav1.4 Sodium Channel Antibody

Our Anti-Nav1.4 sodium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N255/38. It detects rat Nav1.4 sodium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Product Specifications

Background

Sodium channel protein type 4 subunit alpha or Nav1.4 sodium channel is encoded by the gene SCN4A. Nav1.4 is a member of the voltage gated sodium ion channel family. Nav1.4 is an alpha type, pore-forming subunit. It is expressed in skeletal muscle and functions in muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength. Diseases associated with this gene include forms of myotonia and periodic paralysis disorders.

Short Description

Our Anti-Nav1.4 sodium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N255/38. It detects mouse and rat Nav1.4 sodium channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.

Synonyms

Sodium channel protein type 4 subunit alpha (Mu-1) (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)

Gene Name

Scn4a

UniProt

P15390

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Fusion protein amino acids 269-386 (Repeat I external pore between S5 and S6) of rat Nav1.4 (accession number P15390) produced recombinantly in E. Coli

Target

Nav1.4 sodium channel

Clonality

Monoclonal

Isotype

IgG2a

Clone

N255/38

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA

Field of Research

Ion Channels and Modulators/Na+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

>200 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

Unconjugated

RRID

AB_2716260

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