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Anti-Slo1/BKAlpha Potassium Channel Antibody FL594 Conjugate

Selected Variant

75-421-FL594

Size: 200 µL

Our Anti-Slo1/BKAlpha potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L6/48. It is KO validated, detects mouse and rat Slo1/BKAlpha potassium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Calcium-activated potassium channel subunit alpha-1, Potassium Calcium-Activated Channel Subfamily M Alpha 1 or Slo1/BKalpha is encoded by the gene KCNMA1. BKalpha binds to one of 4 different beta subunits to form a channel in the calcium activated large conductance (MaxiK channel) family. This potassium channel is activated by membrane depolarization or an increase in cytosolic ca2+ and mediated the export of K+. BKalpha is involved with various cell processes including contraction of smooth muscle, regulation of transmitter release, innate immunity and regulation of membrane potential. Diseases associated with KCNMA1 include forms of Epilepsy and Developmental Delay Cerebellar Atrophy and Seizures.

Short Description

Our Anti-Slo1/BKAlpha potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L6/48. It is KO validated, detects mouse and rat Slo1/BKAlpha potassium channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K (VCA) alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (mSlo1) (Slowpoke homolog) (Slo homolog) (mSlo)

Gene Name

Kcnma1 Kcnma

UniProt

Q08460-2

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Fusion protein amino acids 690-1196 (cytoplasmic C-terminus) of mouse Slo1 (accession number Q08460) produced recombinantly in E. Coli

Target

Slo1/BKAlpha potassium channel

Clonality

Monoclonal

Isotype

IgG1

Clone

L6/48

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

110-130 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

ICC Quality Control

1

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

RRID

AB_2940398

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