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Anti-ANO6/TMEM16F Antibody FL490 Conjugate

Our Anti-ANO6/TMEM16F mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N429/19. It is KO validated, detects human, mouse, and rat ANO6/TMEM16F, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Anoctamin-6, Transmembrane Protein 16F or -ANO6/TMEM16F is encoded by the gene ANO6. ANO6 belongs to the anoctamin family of membrane proteins many of which are calcium-activated chloride channels. ANO6 plays a role as a regulator of phospholipid scrambling in platelets (which is involved in blood clotting) . ANO6 is expressed in epithelial tissues. Diseases associated with ANO6 include Scott Syndrome and Miyoshi Muscular Dystrophy 3.

Short Description

Our Anti-ANO6/TMEM16F mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N429/19. It is KO validated, detects human, mouse, and rat ANO6/TMEM16F, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)

Gene Name

ANO6 TMEM16F

UniProt

Q4KMQ2

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1-294 (cytoplasmic N-terminus) of human ANO6 (accession number Q4KMQ2) produced recombinantly in E. Coli

Target

ANO6/TMEM16F

Clonality

Monoclonal

Isotype

IgG2b

Clone

N429/19

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/Other Ion Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

110 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with ANO5/TMEM16E

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

RRID

AB_2940388

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