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Anti-GABA-A-R-Alpha5 Antibody

Our Anti-GABA-A-R-Alpha5 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N415/24. It is KO validated, detects human and mouse GABA-A-R-Alpha5, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Product Specifications

Background

Gamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit or GABA (A) Receptor, Alpha 5 is encoded by the gene GABRA5. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR alpha5 is highly expressed in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Disorders involving the GABRA5 gene include Angelman Syndrome, Prader-willi syndrome and childhood absence epilepsy.

Short Description

Our Anti-GABA-A-R-Alpha5 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N415/24. It is KO validated, detects human, mouse, and rat GABA-A-R-Alpha5, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-5 (GABA (A) receptor subunit alpha-5)

Gene Name

GABRA5

UniProt

P31644

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA-A-R-Alpha5 (accession number P31644) produced recombinantly in E. Coli

Target

GABA-A-R-Alpha5

Clonality

Monoclonal

Isotype

IgG1

Clone

N415/24

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA

Field of Research

Neurotransmitter Receptors

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

55 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:500

Specificity

Does not cross-react with GABA-A-R-Alpha2 (or other GABAA

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

Conjugate

Unconjugated

RRID

AB_2491187

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