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Anti-Clcn5 Antibody FL594 Conjugate

Our Anti-Clcn5 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N406/47. It detects human, mouse, and rat Clcn5, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Chloride Voltage-Gated Channel 5, CLCN5 or H (+) /Cl (-) exchange transporter 5 is encoded by the gene CLCN5 and is a member of the voltage-gated chloride channel (ClC) family. CLCN5 is a proton-coupled chloride transporter. CLCN5 is involved in the acidification of the endosome lumen and is thought to play an important role in renal tubular function. CLCN5 is expressed in kidney, aortic and coronary vascular smooth muscle. Diseases associated with CLCN5 include Dent Disease 1 and X-Linked Recessive Hypophosphatemic Rickets.

Short Description

Our Anti-Clcn5 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N406/47. It detects human, mouse, and rat Clcn5, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

H (+) /Cl (-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5)

Gene Name

Clcn5

UniProt

P51796

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 568-746 (C-terminus) of rat Clcn5 (accession number P51796) produced recombinantly in E. Coli

Target

Clcn5

Clonality

Monoclonal

Isotype

IgG1

Clone

N406/47

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Transporter Proteins

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

90 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Clcn4

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

RRID

AB_2940318

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