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Anti-Pan-Kvbeta Potassium Channel Antibody FL490 Conjugate

Our Anti-Pan-Kvbeta potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K25/73. It detects human, mouse, and rat Pan-Kvbeta potassium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

The ß subunits of voltage-gated potassium channels are members of the potassium channel, voltage-gated, shaker-related subfamily. Kvβs are cytoplasmic subunits that modulate the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. There are three ß subunits (Kvß1, Kvß2, Kvß3) which are coded by three different genes. Additionally, there is alternative splicing of these three genes, further diversifying the functions and tissue expression of the family.

Short Description

Our Anti-Pan-Kvbeta potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K25/73. It detects human, mouse, and rat Pan-Kvbeta potassium channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K (+) channel subunit beta-1) (Kv-beta-1) Voltage-gated potassium channel subunit beta-3 (K (+) channel subunit beta-3) (Kv-beta-3) (RCK beta3) Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K (+) channel subunit beta-2) (Kv-beta-2)

Gene Name

Kcnab1 Kvb1 Kcnab3 Ckbeta3 Kcnab2 Ckbeta2 Kcnb3

UniProt

Q13303

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 350-367 (EIDSILGNKPYSKKDYRS, C-terminus) of human Kvbeta2 (accession number Q13303)

Target

Pan-Kvbeta potassium channel

Clonality

Monoclonal

Isotype

IgG1

Clone

K25/73

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/K+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

40 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Reacts with Kvbeta1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

RRID

AB_2940288

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