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Anti-Navbeta3 Na+ Channel Antibody FL594 Conjugate

Our Anti-Navbeta3 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N396/29. It detects mouse and rat Navbeta3 Na+ channel, and is purified by Protein A chromatography. It is great for use in ICC.

Product Specifications

Background

Sodium channel subunit beta-3 or Navbeta3 Na+ channel is encoded by SCN3B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß3 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß3 is expressed in many tissues, including the central and peripheral nervous system, heart and pancreatic endocrine cells. Diseases associated with SCN3A include forms of Epilepsy and Encephalopathy.

Short Description

Our Anti-Navbeta3 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N396/29. It detects mouse and rat Navbeta3 Na+ channel, and is purified by protein a chromatography. It is great for use in ICC.

Synonyms

Sodium channel subunit beta-3

Gene Name

Scn3b

UniProt

Q9JK00

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Fusion protein amino acids 1-215 (full-length) of rat Navbeta3 (accession number Q9JK00) produced recombinantly in E. Coli

Target

Navbeta3 Na+ channel

Clonality

Monoclonal

Isotype

IgG2b

Clone

N396/29

Type

Primary Antibody

Applications

ICC

Field of Research

Ion Channels and Modulators/Na+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

40 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Navbeta1, Navbeta2 or Navbeta4

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

RRID

AB_2940286

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