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Anti-Thyroid Hormone Receptor Beta1 Antibody FL650 Conjugate

Our Anti-Thyroid hormone receptor beta1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N402/46. It detects human, mouse, and rat Thyroid hormone receptor beta1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000) . Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005) .

Short Description

Our Anti-Thyroid hormone receptor beta1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N402/46. It detects human, mouse, and rat Thyroid hormone receptor beta1, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)

Gene Name

THRB ERBA2 NR1A2 THR1

UniProt

P10828

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1-461 (full-length) of human Thyroid hormone receptor beta1 (accession number P10828) produced recombinantly in E. Coli

Target

Thyroid hormone receptor beta1

Clonality

Monoclonal

Isotype

IgG1

Clone

N402/46

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Cell Signaling/Neurogenesis and Development/Transcription Regulation

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

60 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Thyroid hormone receptor beta2 or alpha1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2940279

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