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Anti-GABA-A-R-Alpha2 Antibody FL650 Conjugate

Our Anti-GABA-A-R-Alpha2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N399/19. It is KO validated, detects mouse and rat GABA-A-R-Alpha2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Gamma-aminobutyric acid receptor subunit alpha-2 or GABA AR-Alpha2 is encoded by the gene GABRA2. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR-Alpha2 is primarily expressed in brain at the cell junction, synapse, and the postsynaptic cell membrane. Diseases associated with GABRA2 include Alcohol Dependence and Alcohol Use Disorder.

Short Description

Our Anti-GABA-A-R-Alpha2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N399/19. It is KO validated, detects mouse and rat GABA-A-R-Alpha2, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-2 (GABA (A) receptor subunit alpha-2)

Gene Name

Gabra2 Gabra-2

UniProt

P23576

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Fusion protein amino acids 350-385 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha2 (accession number P23576) produced recombinantly in E. Coli

Target

GABA-A-R-Alpha2

Clonality

Monoclonal

Isotype

IgG1

Clone

N399/19

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Neurotransmitter Receptors

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

55 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with GABA-A-R-Alpha1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2940275

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