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Anti-Ankyrin-R Antibody FL594 Conjugate

Our Anti-Ankyrin-R mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N388A/10. It is KO validated, detects human, mouse, and rat Ankyrin-R, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Ankyrin-1 or -Ankyrin-R is encoded by the gene ANK1. Ankyrin R is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin R is found expressed in erythrocytes, skeletal muscle and brain. Diseases associated with this gene include Spherocytosis.

Short Description

Our Anti-Ankyrin-R mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N388A/10. It is KO validated, detects human, mouse, and rat Ankyrin-R, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)

Gene Name

ANK1 ANK

UniProt

P16157

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R (accession number P16157) produced recombinantly in E. Coli

Target

Ankyrin-R

Clonality

Monoclonal

Isotype

IgG2b

Clone

N388A/10

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Scaffold Proteins

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

200 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Ankyrin-B or Ankyrin-G

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

RRID

AB_2940266

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