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Anti-Navbeta2 Na+ Channel Antibody

Our Anti-Navbeta2 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N395/68. It is KO validated, detects mouse and rat Navbeta2 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Product Specifications

Background

Sodium channel subunit beta-2 or Navbeta2 Na+ channel is encoded by SCN2B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß2 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß2 is expressed in many tissues, including the central and peripheral nervous system, heart, and skeletal muscle. Diseases associated with this gene include Familial Atrial Fibrillation

Short Description

Our Anti-Navbeta2 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N395/68. It is KO validated, detects mouse and rat Navbeta2 Na+ channel, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.

Synonyms

Sodium channel subunit beta-2

Gene Name

Scn2b Gm183

UniProt

Q56A07

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Fusion protein amino acids 1-215 (full-length) of mouse Navbeta2 (accession number Q56A07) produced recombinantly in E. Coli

Target

Navbeta2 Na+ channel

Clonality

Monoclonal

Isotype

IgG2b

Clone

N395/68

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA

Field of Research

Ion Channels and Modulators/Na+ Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

40 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Navbeta1, Navbeta3 or Navbeta4 (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

WB Brain Quality Control

1

Conjugate

Unconjugated

RRID

AB_2315896

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