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Anti-PSD-95 MAGUK Scaffold Protein Antibody

Our Anti-PSD-95 MAGUK scaffold protein mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K28/74. It is KO validated, detects human, mouse, and rat PSD-95 MAGUK scaffold protein, and is purified by Protein A chromatography. It is great for use in AT, IHC, ICC, WB.

Product Specifications

Background

PSD-95 is a member of the MAGUK (membrane associated guanylate kinase) family (which also includes PSD-93, SAP97 and SAP102) and functions as a scaffold protein that can cluster membrane receptors, ion channels, including NMDA receptor subunits, Kv1 potassium channels and Caspr2. The protein is encoded by DLG4, contains hallmark PDZ, SH3 and GuK domains and is found at post synaptic densities where it plays an important role in the formation and maintenance of synaptic junctions (Zhou and Blumberg, 2003) . Indeed, overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. Antibodies against PSD95/DLG4 are frequently used in conjunction with pre-synaptic markers to localize synapses by microscopy

Short Description

Our Anti-PSD-95 MAGUK scaffold protein mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K28/74. It is KO validated, detects human, mouse, non-human primate, and rat PSD-95 MAGUK scaffold protein, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA, AT.

Synonyms

Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

Gene Name

DLG4 PSD95

UniProt

P78352

Host

Mouse

Reactivity

Human, Mouse, Non-Human Primate, and Rat

Immunogen

Fusion protein amino acids 77-299 (PDZ domains 1 and 2) of human PSD-95 (accession number P78352) produced recombinantly in E. Coli

Target

PSD-95 MAGUK scaffold protein

Clonality

Monoclonal

Isotype

IgG1

Clone

K28/74

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA, AT

Field of Research

Scaffold Proteins

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

95-110 kDa (varies with cell background due to phosphorylation)

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

IHC Dilution

1:1000

WB Dilution

1:1000

Specificity

Does not cross-react with DLG1/SAP97

ICC Dilution

1:1000

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

WB Brain Quality Control

1

Conjugate

Unconjugated

RRID

AB_2315909

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