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Anti-TRIP8B (Exon 1A/5 Junction) Antibody FL650 Conjugate

Our Anti-TRIP8b (exon 1a/5 junction) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N291C/22. It is KO validated, detects mouse and rat TRIP8b (exon 1a/5 junction), and is purified by Protein A chromatography. It is great for use in ICC.

Product Specifications

Background

PEX5-related protein, Peroxisomal Biogenesis Factor 5 Like, TPR-containing Rab8b-interacting protein or TRIP8b is encoded by the gene Pex5l. It is a member of the peroxisomal targeting signal receptor family. TRIP8b is a cytoplasmic accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. TRIP8b interacts with the carboxyl-terminal region of HCN channels and regulates their cell-surface expression to the dendrites in many types of neurons. TRIP8b plays a role in regulation of HCN channel cyclic nucleotide kinetics. TRIP8b is expressed in the brain. Diseases associated with PEX5L include Rhizomelic Chondrodysplasia Punctata, Type 5 and Rhizomelic Chondrodysplasia Punctata, Type 2.

Short Description

Our Anti-TRIP8b (exon 1a/5 junction) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N291C/22. It is KO validated, detects mouse and rat TRIP8b (exon 1a/5 junction), and is purified by protein a chromatography. It is great for use in ICC.

Synonyms

PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b)

Gene Name

Pex5l Pex2 Pex5r Pxr2

UniProt

Q8C437

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Synthetic peptide amino acids 1-12 (MYQGHMQLVNEQ, exon 1a (yellow) and exon 5 (green) of constant region) of mouse TRIP8b (accession number Q8C437)

Target

TRIP8b (exon 1a/5 junction)

Clonality

Monoclonal

Isotype

IgG1

Clone

N291C/22

Type

Primary Antibody

Applications

ICC

Field of Research

Ion Channels and Modulators/Other Ion Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

60 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Specific for exon 1a/5 junction (does not react

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

ICC Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2940155

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