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Anti-Histone H2A.Z Acetyl-Lys4/7/11 Antibody

Our Anti-Histone H2A.Z acetyl-Lys4/7/11 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N299/39. It detects human, mouse, and rat Histone H2A.Z acetyl-Lys4/7/11, and is purified by Protein A chromatography. It is great for use in DB, ELISA.

Product Specifications

Background

H2A.Z Variant Histone 1 is encoded by the gene H2AZ1. H2AZ1 is a member of the histone H2A family. H2AZ1 is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic fatality. H2AZ1 is expressed in 239 organs with the highest levels in the myometrium. Diseases associated with H2AZ1 include testicular spermatocytic seminoma.

Short Description

Our Anti-Histone H2A.Z acetyl-Lys4/7/11 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N299/39. It detects human, mouse, and rat Histone H2A.Z acetyl-Lys4/7/11, and is purified by protein a chromatography. It is great for use in ICC, ELISA.

Synonyms

Histone H2A.Z (H2A/z)

Gene Name

H2AFZ H2AZ

UniProt

P0C0S5

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 2-15 (AGG[acetyl-K]AG[acetyl-K]DSG[acetyl-K]AKT) of human Histone H2A.Z (accession number P0C0S5)

Target

Histone H2A.Z acetyl-Lys4/7/11

Clonality

Monoclonal

Isotype

IgG1

Clone

N299/39

Type

Primary Antibody

Applications

ICC, ELISA

Field of Research

Epigenetics

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

13 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with unacetylated Histone H2A.ZDoes not cross-react with Histones H2A acetyl-Lys4/8 or H4 acetyl-Lys4/7/11/15

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

Conjugate

Unconjugated

RRID

AB_2315848

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