Apocynin
Product Specifications
UNSPSC Description
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
Target Antigen
NADPH Oxidase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Apocynin.html
Purity
99.99
Solubility
DMSO : ≥ 100 mg/mL|H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC(C1=CC=C(O)C(OC)=C1)=O
Molecular Weight
166.176
References & Citations
[1]Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102.|[2]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[3]Sun J, et.al. Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass. Sci Rep. 2015 Dec 21;5:18572. |[4]Yamasaki M, et.al. Selective inhibition by apocynin of the proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. Biosci Biotechnol Biochem. 2012;76(6):1177-81. |[5]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81(5):636-48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0088/Apocynin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0088/Apocynin-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
498-02-2
Available Sizes
Curated Selection
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