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Apocynin

Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan -induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].

Product Specifications

CAS Number

498-02-2

Product Name Alternative

Acetovanillone

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

NADPH Oxidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Apocynin.html

Purity

99.99

Solubility

DMSO : ≥ 100 mg/mL|H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C9H10O3

Molecular Weight

166.18

Precautions

H315, H319, H335

References & Citations

[1]Stolk J, et al. Am J Respir Cell Mol Biol, 1994, 11 (1), 95-102.|[2]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[3]Sun J, et.al. Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass. Sci Rep. 2015 Dec 21;5:18572. |[4]Yamasaki M, et.al. Selective inhibition by apocynin of the proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. Biosci Biotechnol Biochem. 2012;76 (6) :1177-81. |[5]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81 (5) :636-48.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

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