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Anti-NR2A Glutamate Receptor Antibody

Our Anti-NR2A glutamate receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N327A/38. It detects human, mouse, and rat NR2A glutamate receptor, and is TC supernatant. It is great for use in IHC, ICC, WB.

Product Specifications

Background

Glutamate receptor NMDA2A or GluN2A/NR2A glutamate receptor is a member of the glutamate-gated ion channel family. NR2A is a subunit of the ligand-gated ion channel with high calcium permeability and voltage-dependent sensitivity to magnesium. NR2A is expressed throughout the brain, including striatum, forbrain, cerebellum (at protein level) brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer. It is found at the postsynaptic cell membrane, dendritic spine, synapse, and cytoplasmic vesicle membrane. A variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia are associated with mutations in the NR2A gene.

Short Description

Our Anti-NR2A glutamate receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N327A/38. It detects human, mouse, and rat NR2A glutamate receptor, and is tc supernatant. It is great for use in WB, IHC, ICC, ELISA.

Synonyms

Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)

Gene Name

Grin2a

UniProt

Q00959

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat NR2A (accession number Q00959) produced recombinantly in E. Coli

Target

NR2A glutamate receptor

Clonality

Monoclonal

Isotype

IgG2b

Clone

N327A/38

Type

Primary Antibody

Applications

WB, IHC, ICC, ELISA

Field of Research

Neurotransmitter Receptors

Concentration

Lot dependent

Format

TC Supernatant

Buffer

Supernatant is provided in cell culture medium with 0.1% sodium azide as anti-microbial

Molecular Weight

170 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with NR2B

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

ICC Quality Control

1

Conjugate

Unconjugated

RRID

AB_2315843

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