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Anti-TRPML3/Mucolipin-3 Antibody

Our Anti-TRPML3/Mucolipin-3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N268/19. It detects human, mouse, and rat TRPML3/Mucolipin-3, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Product Specifications

Background

Mucolipin-3, Transient receptor potential cation channel, mucolipin subfamily, member 3 or TrpML3 is encoded by the gene MCOLN3. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels and acts as an inwardly rectifying cation channel. TrpML3 is found in the cochlea, olfactory kidney, lung and hair cells and strial cells of the inner ear. The protein localizes to the plasma membrane, endosomes, and lysosomes of cells. Mutations in this gene in mice result in auditory hair cell death and deafness

Short Description

Our Anti-TRPML3/Mucolipin-3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N268/19. It detects human, mouse, and rat TRPML3/Mucolipin-3, and is purified by protein a chromatography. It is great for use in WB, ICC, ELISA.

Synonyms

Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3)

Gene Name

MCOLN3

UniProt

Q8TDD5

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 269-285 (CKDWHVSGSIQKNTHYM, extracellular N-terminus) of human TRPML3 (accession number Q8TDD5)

Target

TRPML3/Mucolipin-3

Clonality

Monoclonal

Isotype

IgG2a

Clone

N268/19

Type

Primary Antibody

Applications

WB, ICC, ELISA

Field of Research

Ion Channels and Modulators/Trp Channels

Concentration

1 mg/mL

Format

Purified by Protein A chromatography

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Molecular Weight

64 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

ICC Quality Control

1

Conjugate

Unconjugated

RRID

AB_11000726

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