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Anti-GluN1/NR1 Glutamate Receptor Antibody FL650 Conjugate

Selected Variant

75-272-FL650

Size: 200 µL

Our Anti-GluN1/NR1 glutamate receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N308/48. It detects human, mouse, and rat GluN1/NR1 glutamate receptor, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Glutamate receptor 1, NMDA 1, or GluN1/NR1 also known as subunit 1 of the N-methyl-D-aspartate (NMDA) receptor. It is a member of the glutamate receptor channel superfamily and is a heteromeric glutamate-gated calcium ion channel. GluN1 is essential for synaptic function in the brain. GluN1 is expressed throughout the brain in cerebellum, thalamus, olfactory bulb and cortex in the membrane at postsynaptic density. GluN1 plays a key role in synaptogenesis, synaptic plasticity, memory acquisition and learning. Mutations in the GluN1 gene are associated with intellectual disability and cortical visual impairment and movement disorders.

Short Description

Our Anti-GluN1/NR1 glutamate receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N308/48. It detects human, mouse, and rat GluN1/NR1 glutamate receptor, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)

Gene Name

Grin1 Nmdar1

UniProt

P35439-2

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1 (accession number P35439) produced recombinantly in E. Coli

Target

GluN1/NR1 glutamate receptor

Clonality

Monoclonal

Isotype

IgG1

Clone

N308/48

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Neurotransmitter Receptors

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

105 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2939979

Price

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