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Anti-Clcn3 Antibody FL650 Conjugate

Our Anti-Clcn3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N258/5. It is KO validated, detects human, mouse, and rat Clcn3, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Chloride Voltage-Gated Channel 3, CLCN3 or H (+) /Cl (-) exchange transporter 3 is encoded by the gene CLCN3 and is a member of the voltage-gated chloride channel (ClC) family. CLCN3 is a proton-coupled chloride transporter. It plays a role in acidification of endosomes and synaptic vesicle lumen. CLCN3 implicated in vesicle trafficking, neuronal cell function and short term memory. CLCN3 is expressed in several tissues including brain, aortic and coronary vascular smooth muscle cells, bronchus and colon. Diseases associated with this gene include Dent Disease 1 and Cystic Fibrosis

Short Description

Our Anti-Clcn3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N258/5. It is KO validated, detects human, mouse, and rat Clcn3, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

H (+) /Cl (-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)

Gene Name

CLCN3

UniProt

P51790

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 98-115 (CKDRERHRRINSKKKESA, cytoplasmic N-terminus) of rat Clcn3 (accession number P51792)

Target

Clcn3

Clonality

Monoclonal

Isotype

IgG1

Clone

N258/5

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Transporter Proteins

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

90 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not cross-react with Clcn4 or Clcn5 (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2939939

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