Serum thymic factor

Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072) -induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases[1][2][3][4].

Product Specifications

CAS Number

[63958-90-7]

Product Name Alternative

Thymulin; Thymic factor

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

ERK

Type

Peptides

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/serum-thymic-factor.html

Purity

98.09

Solubility

10 mM in DMSO

Smiles

NC(C[C@@H](C(O)=O)NC([C@H](CO)NC(CNC(CNC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](C)NC([C@@H]1CCC(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C33H54N12O15

Molecular Weight

858.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Dardenne M, et al. Role of thymulin or its analogue as a new analgesic molecule. Ann N Y Acad Sci. 2006 Nov;1088:153-63.|[2]Mizutani M, et al. In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice. Arch Virol. 1996;141 (1) :73-83.|[3]Kohda Y, et al. Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Nov;28 (11) :2087-91.|[4]Pardo J, et al. Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin[J]. Physiological Mini Reviews (PMR), 2012, 6.